The Biohackers Guide to Controlling Satiety Without Ozempic: Fat loss special

Your Fat Loss journey Made Easy! (Really) #5

Very recently, one of my valued members requested a guide on controlling satiety naturally without the help of GLP-1s like Ozempic and Retatrutide. So, I thought I would happily oblige his request and share my knowledge on the subject.

This masterclass guide will be solely dedicated to satiety control and fat loss, incorporating tried and battle-tested techniques that have aided me in fat loss and satiety control throughout my athletic career and everyday life, as well as with clients.

So, without further ado, let us begin.

To first understand satiety and fat loss, we need to learn the hormones responsible. To break it down in simple terms, I'll be focusing on three hormones that are predominantly involved in the process - what I like to call the 'holy trinity.' From there, we can dive into various techniques that we can use to control and leverage these hormones to aid in your fat loss journey. As always, these will be broken down into lifestyle changes, dietary approaches, and supplemental strategies, following the format of all previous guides that have come before it.

By the end of this article, you will be readily equipped with an artillery of techniques so strong that every fat cell will quake with fear at your very gaze.

Just ask my visceral fat rating

Let us leptin….i mean begin

Introduction to Satiety Hormones

Leptin

Leptin is a hormone primarily produced by adipose tissue (fat cells) that plays a critical role in regulating your energy balance, appetite, and metabolism.

Often referred to as the "satiety hormone" or "starvation hormone," leptin communicates with your brain to signal when the body has enough stored energy (fat) and to regulate hunger accordingly.

Modern Challenges

In modernity, due to excessive eating and over-storage of fatty acids within fat cells:

• Excess storage of fatty acids that are never used up leads to increased fat cell size

• Overeating and high-calorie diets cause the body to store too many triglycerides

As a result, over time these fat cells begin to grow (hypertrophy), and the number of fat cells may also increase in number (hyperplasia).

This is interesting because it leads to improper leptin signaling, also known as leptin resistance. Akin to insulin resistance when you eat too many carbohydrates or sugar molecules, your body no longer reacts to insulin in the same way.

Glucagon-like Peptide-1 (GLP-1)

Next up we have GLP-1, the peptide hormone that has been on everyone's tongues since the rise of the infamous Ozempic, which is a GLP-1 agonist.

GLP-1 is an incretin hormone primarily produced in the intestines in response to food intake. It plays a crucial role in metabolic regulation and appetite control.

Key Functions

Appetite and Satiety

• Reduces food intake by promoting feelings of fullness

• Slows gastric emptying (food moves more slowly through stomach)

• Signals the brain's satiety centers (similar to leptin)

• Reduces appetite and cravings

Blood Sugar Regulation

• Stimulates insulin release from pancreatic beta cells

• Suppresses glucagon secretion

• Improves insulin sensitivity

• Helps maintain stable blood glucose levels

Metabolic Effects

• Reduces fat storage (Adipocytes)

• Improves metabolic rate (BMR)

• Enhances fat oxidation (Beta oxidation)

• Protects pancreatic beta cells

Ghrelin: The Hunger Hormone

Now last but not least, we have the end of the holy trinity, also known as ghrelin, the hunger hormone - basically the yin to leptin's yang.

Key Functions

Appetite Regulation

• Stimulates hunger and food intake

• Increases stomach acid production

• Enhances gastric motility

• Promotes meal initiation

• Influences food reward behaviors