Biohacker

Biohacker

How to Actually Boost Testosterone (The Definitive Guide)

Going deeper into what matters #34

Oct 29, 2025
∙ Paid

I’m disgusted.

Not at you. At the endless stream of surface-level testosterone advice flooding your substack and instagram feed.

“Eat more cholesterol.” “Lift heavy.” “Get sunlight.”

It’s not wrong. It’s just incomplete. These guides touch the surface but never dive into the machinery where testosterone is made, what signals its production, how your mitochondria drive your hormones.

I’m going to change that.

I’m 27. Natural. I compete in martial arts, run a business, have a girlfriend and a child. I’m all guns blazing. And I drew 922 ng/dL on my last blood test with high free testosterone.

How? Because I understand the systems.

And now, I’m going to teach you.

Part 1: Your Leydig Cells Are Waiting for a Signal

Testosterone isn’t made in your muscles or your brain. It’s made in the Leydig cells of your testes.

These cells are steroidogenic factories that convert cholesterol into testosterone through enzymatic reactions occurring inside your mitochondria:

Cholesterol → Pregnenolone → DHEA → Andros…

Keep reading with a 7-day free trial

Subscribe to Biohacker to keep reading this post and get 7 days of free access to the full post archives.

Already a paid subscriber? Sign in
© 2025 Biohacker
Privacy ∙ Terms ∙ Collection notice
Start your SubstackGet the app
Substack is the home for great culture